پیوست(۳)

دیفرکتوگرام XRD نانو کامپوزیت
Abstract
Drug quality is increased dramatically by removing of its impurities.  The molecularly imprinted polymers have the essential advantages such as high selectivity and chemical stability and low price that can be used as an effective method with high efficiency for obtained pure drug.
In this project، a molecularly  imprinted polymer for separation of  ۶-hydroxy -2 4 5-tri amino pyrimidine as impurity of folic acid was synthesized.  A new molecularly imprinted polymer was synthesized using, methacrylic acid (functional monomer) ،ethylene glycol dimethacrylate (cross-linker) ، ۲,۲-azobisisobutironitril (intiator) ، ۶-hydroxy -2 4 5-tri amino pyrimidine (template)   ، and toluene and acetonitrile (solvent) and silica nanoparticle. This process was causing a non-covalent، bulk،thermal radical polymerization.
To compare the performance of this polymer, a molecularly non- imprinted polymer was prepared under the same conditions without the of template molecule. The synthesized polymers were characterized by FT-IR and XRD spectroscopy. In addition, various parameters such as pH ، time ، type of eluent for elution of impurity form polymer wereoptimized.
Keywords: molecularly imprinted polymer،foulic acid، molecularly non-imprinted polymer
Islamic Azad University
Damghan Branch
Faculty of Science Department of Chemistry
M.Sc Thesis of Organic chemistry
Title
Synthesis of Molecularly Methacrylate polymer contains specefic nano hole for Separation of 6-hydroxy -2 4 5-tri amino pyrimidine as impurity of folic acid drug
Supervisor
Dr.Hamid Hashemi-Moghaddam
Advisor
Dr.Masoud Shaabanzadeh
By
Elaheh Vahedi
September 2013

1. 1. Jöns Jacob Berzelius ↑

1. 1. Homopolymer ↑

1. 1. Copolymer ↑

1. 1. Terpolymer ↑

1. 1. Heteropolymer ↑

1. 1. Step-growth polymerization ↑

1. 1. Chain-growth polymerization ↑

1. 1. Hsieh & Quirk ↑

1. 1. Blackeley & Twaits ↑

1. 1. Mark et al.
      ↑

1. 1. stevenson ↑

1. 1. Pojman et al. ↑

1. 1. Chain transfer ↑

1. 1. Solid phase extraction ↑

1. 1. Octadecyl ↑

1. 1. Silanol ↑

1. 1. Graphitized carbon black ↑

1. 1. Porous graphitic carbon ↑

1. 1. Yan et al. ↑

1. 1. Molecularly imprinted solid phase extraction ↑

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1. 1. Molecularly Imprinted Polymer ↑

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